Chain Termination Steps in Nonribosomal Peptide Synthetase Assembly Lines: Directed Acyl-S-Enzyme Breakdown in Antibiotic and Siderophore Biosynthesis

Autor:	C. Gary Marshall, Thomas A. Keating, David E. Ehmann, Christopher T. Walsh, John W. Trauger, Rahul M. Kohli
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Stereochemistry Organic Chemistry Peptide Biology Chain termination Biochemistry Amino acid Enzyme catalysis chemistry.chemical_compound Enzyme Monomer chemistry Biosynthesis Nonribosomal peptide Molecular Medicine Molecular Biology
Zdroj:	ChemBioChem. 2:99-107
ISSN:	1439-7633 1439-4227
DOI:	10.1002/1439-7633(20010202)2:2<99::aid-cbic99>3.0.co;2-3
Popis:	A large number of therapeutically useful natural peptides areproduced nonribosomally by assembly line enzymology, involv-ing multidomain and multimodular catalysts that activate andassemble constituent amino acid monomers into oligopeptides.The peptide chains released (Scheme 1) can be final productssuch as cyclosporin (1)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d0cf39e60f5c33a8b5dd8061c01729cf https://doi.org/10.1002/1439-7633(20010202)2:2<99::aid-cbic99>3.0.co Zobrazit plný text záznamu Plný text