Minocycline as a Cause of Drug-Induced Autoimmune Hepatitis
| Autor: | Neal S. Goldstein, Stuart C. Gordon, Nasser Bayati, Ann L. Silverman |
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| Rok vydání: | 2000 |
| Předmět: | |
| Zdroj: | American Journal of Clinical Pathology. 114:591-598 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1309/kv2j-vx6q-l95v-vde4 |
| Popis: | We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1). We compared the serum laboratory values and liver biopsy findings from group 1 with those from 10 patients with sporadic autoimmune hepatitis (group 2). All patients in group 1 had positive serum antinuclear antibody titers, but none had positive serum anti-smooth muscle antibody titers. The morphologic findings of group 1 biopsies were those of autoimmune hepatitis in all 4 patients. In addition, 1 of these biopsy specimens also had scattered single eosinophils, unlike autoimmune hepatitis. The mean histologic activity index scores for patients in groups 1 and 2, respectively, were 6.7 and 5.4. No patients in group 1 had marked bridging fibrosis or cirrhosis, compared with 4 of 10 patients in group 2. Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis. The absence of eosinophils does not exclude the possibility of a minocycline cause. In the absence of clinical or morphologic differences, a recent ingestion of minocycline should be excluded before the diagnosis of sporadic autoimmune hepatitis is established. Whether the drug is unmasking latent autoimmune hepatitis is unclear. |
| Databáze: | OpenAIRE |
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