The natural history of untreated hepatocellular carcinoma

Autor: Saito S, Kenji Katakai, Yoshiaki Hashimoto, Takehiko Abe, Daisuke Kanda, Toshihiko Yamada, Takashi Kosone, Keiichirou Yuasa, Mariko Kurosaki, Takeaki Nagamine, Satoru Kakizaki, Hisashi Takayama, Masatomo Mori, Akira Kojima, Hitoshi Takagi
Rok vydání: 1998
Předmět:
Zdroj: International Journal Of Clinical Oncology. 3:299-303
ISSN: 1437-7772
1341-9625
Popis: Background. Although early diagnosis and treatment of hepatocellular carcinoma (HCC) has become available through advances in diagnostic imaging and therapeutic modalities, there is still a need for recent data on the prognosis of untreated HCC. Therefore, we evaluated the natural history of patients with untreated HCC from various clinical viewpoints. Methods. Data from 70 untreated HCC patients (57 men, 13 women; aged 43–94 years) diagnosed from June 1992 to May 1997 at seven hospitals in Gunma Prefecture, Japan, were analyzed. Results. The overall mean survival was 5.3 ± 7.6 months from diagnosis to death. The median survival was 2.0 months from diagnosis to death; 12.0 months for tumor stage I, 6.8 months for tumor stage II, 8.6 months for tumor stage III, 2.0 months for tumor stage IV-A, and 2.0 months for tumor stage IV-B. According to clinical stage, the median length of survival of clinical stage I patients was 4.3 months; stage II, 4.3 months; and stage III, 1.4 months. In the 15 patients who refused any anti-cancer treatment, the median survival was 15.2 months and in the 55 patients who could not be given anti-cancer treatment because of poor liver function or advanced cancer the median survival was 1.6 months. The prognosis of patients with HCC complicated by portal thrombus was extremely poor. Multivariate analysis showed that portal thrombus and hypoalbuminemia were significant indicators of poor prognosis. Older patients with HCC had a poor prognosis, although the difference from prognosis in younger patients was not significant. Conclusions. Both tumor stage and clinical stage were correlated with duration of survival from diagnosis in these patients with HCC. The prognosis of untreated patients with HCC was extremely poor. All untreated patients died within 3 years of diagnosis.
Databáze: OpenAIRE
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