P5-06-03: Gene Expression Associated with Breast Cancer Primary and Secondary Resistance to Neoadjuvant Chemotherapy
| Autor: | C. T. Oliveira, Filho Mc Barros, Mak Folgueira, Aps Abreu, Maria Mitzi Brentani, Dirce Maria Carraro, M. L.H. Katayama, J. R. F. Caldeira, Helena Brentani, FK Fujiki, J. C. S. Góes |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Cancer Research. 71:P5-06 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.sabcs11-p5-06-03 |
| Popis: | In breast cancer, neoadjuvant chemotherapy may provide valuable information on tumor resistance mechanisms, as variable degrees of tumor response, from pathological complete response until progressive disease, may be observed. To have a better insight of the resistance process to chemotherapy, we have compared resistant pre chemotherapy samples (representing primary or intrinsic resistance) and residual post chemotherapy from partially responsive tumors (secondary or acquired resistance), by means of their transcriptional profile.Tumors from 36 patients submitted to neoadjuvant chemotherapy (4 cycles doxorrubicin and cyclophosphamide) were collected (12 pre-chemotherapy from primary resistant samples and 24 post chemotherapy from residual samples) and analyzed by cDNA microarray (training set, n=25, 9 resistant; 16 residual) and/or by qRT-PCR (technical validation set, n=11, and biological validation set, n=11; 8 resistant; 14 residual). In samples from the training set analysed using a cDNA microarray platform with 4608 genes (Student's t test; p Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-06-03. |
| Databáze: | OpenAIRE |
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