Comparative Nephrotoxicity and Hepatotoxicity Effects of Kerosene, Gasoline, Liquefied Petroleum Gas and Biomass Fuel Exposure on Male Albino Rats

Autor: Meludu Samuel Chukwuemeka, Ibekailo Sylvester Nnaemeka, Ude Tochukwu, Awalu Chimezie Joseph, Dioka Chudi Emmanuel, Chikezie Onyebuchi Desmond
Rok vydání: 2020
Předmět:
Zdroj: Asian Journal of Research in Biochemistry. :45-52
ISSN: 2582-0516
DOI: 10.9734/ajrb/2020/v7i430147
Popis: The effects of Kerosene, gasoline, and liquefied petroleum gas and biomass fuel exposure on biomarkers of kidney and liver were investigated in male wistar rats. Fifty adult male wistar rats were randomly assigned to five groups of ten animals each. Rats in group A served as control (exposed to fresh air). Group B, C, D and E were exposed to inhalation of kerosene, gasoline, liquefied petroleum gas and biomass fuel (wood smoke) respectively. All the exposures were done using whole body exposure chambers 70 cm x 60 cm x 60 cm measurement for six weeks, 6 days per week. Five millilitres of blood sample were collected and serum extracted at the end of six weeks. The serum concentration of urea, creatinine, uric acid and activities AST, ALT, γGT were determined using Cobas reagent kits manufactured by Roche Diagnostics GmbH, Sandhofer Strasse 116, D-68305 Mannheim, Germany. Values were analysed statistically using SPSS version 23.0. The result shows significant increase in the serum levels of urea, creatinine and uric acid of test groups relative to control (p
Databáze: OpenAIRE