Cognitive impairment in patients with eosinophilic granulomatosis with polyangiitis (EGPA): Service evaluation in a regional severe asthma centre in North-west England
| Autor: | Binita Kane, D Ryan, Sarah Diver, Robert Niven, Leanne Jo Holmes, Steve Fowler |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pediatrics
medicine.medical_specialty medicine.diagnostic_test business.industry Neuropsychology Magnetic resonance imaging medicine.disease Hyperintensity Eosinophilic medicine Physical therapy Eosinophilic vasculitis Cognitive decline Granulomatosis with polyangiitis business Subclinical infection |
| Zdroj: | 1.11 Clinical Problems - Asthma. |
| DOI: | 10.1183/13993003.congress-2016.pa5017 |
| Popis: | Background: Cognitive decline in EGPA is rare. 30% of patients with small vessel vasculitis may have subclinical neuropsychological impairment 1 . Data is limited regarding EGPA alone. Aim: To evaluate prevalence of cognitive impairment in patients with EGPA managed at a regional severe asthma centre in South Manchester, England. Methods: Cases identified where diagnosis of EGPA made by a specialist in eosinophilic vasculitis. Clinical consultations reviewed for subjective evidence of disease-related cognitive decline. Results: N = 16, 11 male, mean age 53. 25% had antibodies to myeloperoxidase (MPO). Cognitive impairment was present in 37.5% (6). Memory loss was described in all 6, poor concentration in 2, slowed speech in 1. 4 of 6 had magnetic resonance (MR) cerebral angiogram and 2 standard MR brain. Frontal white matter hyperintensities were seen on standard MR in 2. All other brain imaging was normal. 5 of 6 were reviewed by a neurologist. Discussion: Evaluation of our service indicates that disease-related cognitive impairment is more prevalent than literature suggests. Further objective evidence is required. This reinforces the importance of a multidisciplinary approach in EGPA. Reference: Frequency and patterns of subclinical cognitive impairment in patients with ANCA-associated small vessel vasculitides. Mattioli et al. J Neurol Sci. 2002. |
| Databáze: | OpenAIRE |
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