| Autor: |
Mirta C. Remesar, Ester Cerdeira Sabino, Ana del Pozo, Michael P. Busch, Allen J. Mayer, Brian Custer |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Transfusion. 55:2499-2504 |
| ISSN: |
0041-1132 |
| Popis: |
BACKGROUND Low-level seroreactive donor samples that are inconsistently detected by different Trypanosoma cruzi immunoassays are common, but the population distribution has not been reported in an endemic region. The objective was to understand the distribution of low-level reactive samples using highly sensitive immunoassays and the relationship with epidemiologic evidence of exposure to T. cruzi. STUDY DESIGN AND METHODS Blood donors (BDs) were recruited in two blood banks located in Chaco province, in northeastern Argentina, from June 2006 to March 2007. Donors completed a Chagas exposure questionnaire and provided blood samples. All samples were tested in parallel with five contemporary and commercially available enzyme immunoassays for T. cruzi and a subgroup by a chemiluminescent assay. RESULTS Of the 1423 enrolled donors, 304 (21.4%) tested positive on all assays while 93 (6.5%) were reactive on at least one assay (inconclusive). Epidemiologic evidence of exposure to T. cruzi was significantly higher among positive and inconclusive donors compared to seronegative BD (p values range from 0.01 to |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text