Homocysteine (Hyc) in prediabetes: An early indicator of Cardiovascular disease
| Autor: | Santosh Eknath Bidwe, P. J. Hisalkar, Neerja Mallick |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | International Journal of Clinical Biochemistry and Research. 6:348-352 |
| ISSN: | 2394-6377 2394-6369 |
| DOI: | 10.18231/j.ijcbr.2019.076 |
| Popis: | Introduction: Diabetes mellitus (DM) is associated with an increased risk of cardiovascular disease (CVD) and mortality. Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are well characterized prediabetes conditions and about half of those proceed with the development of type 2 diabetes. During the pre-diabetic state, the risk of a CVD is modestly increased. The aim of present study is to evaluate serum Homocysteine (Hyc) level in prediabetes and type 2 diabetes patients and find the association between Hyc and other variables. Materials and Methods: This cross sectional descriptive study was conducted on 450 participants. Out of this 150 were type 2 diabetic patients, 150 prediabetes and 150 controls. Homocystine and biochemical parameters were measured. Results: Homocysteine is a sulfur-containing amino acid formed during the metabolism of methionine consider as a an early detection marker in cardiovascular disease elevated in prediabetes patients, type 2 diabetes compared to controls. Conclusion: We observed that homocysteine significantly increased in prediabetes compared to healthy control. Homocysteine levels can indicate the risk of CVD in prediabetic stage. Prediabetes people are under risk of CAD and type 2 diabetes. The evaluation of the Homocysteine levels may improve the early diagnosis of CVD in prediabetes patients. Keywords: Cardiovascular disease, Homocysteine, Nitric Oxide, Prediabetes, Type 2 diabetes. |
| Databáze: | OpenAIRE |
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