Reduced neonatal lung function and wheezing illnesses during the first 5 years of life
| Autor: | Cornelis K. van der Ent, Theo J M Verheij, Anne C. van der Gugten, Nienke van Putte-Katier, Marije Koopman, Cuno S.P.M. Uiterwaal |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | European Respiratory Journal. 42:107-115 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.00214711 |
| Popis: | Studies of reduced neonatal lung function and wheezing illnesses during childhood show conflicting results. The aim of our study was to assess the association between resistance ( R rs ) and compliance ( C rs ) of the respiratory system by using the single occlusion technique (SOT) and prospectively collected wheezing illnesses during the first 5 years of life in a large birth cohort. SOT was performed during natural sleep before the age of 2 months. Information about wheezing illnesses was collected from the electronic patient file. 549 infants had a successful SOT measurement and complete medical records. Every kPa·L −1 ·s −1 increase in R rs was associated with 10% more consultations in the first 3 years of life. Every 10 mL·kPa −1 increase in C rs was associated with a 14% reduction in consultations in the first 3 years of life, 27% in the fourth to fifth years of life, and a lower probability of having asthma at the age of 5 years (OR 0.66). Children with late-onset or persistent wheezing had significant lower C rs values than their peers. An increased neonatal resistance is associated with more wheezing illnesses during infancy, while a reduced neonatal compliance is associated with more wheezing illnesses during the first 5 years of life, a late-onset or persistent wheezing phenotype, and asthma. |
| Databáze: | OpenAIRE |
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