Nuclear analogs of β-lactam antibiotics. XX. Synthesis and X-ray structure determination of exocyclic penems: sulfur analogs of clavulanic acid

Autor:	Gilles Caron, Marcel Menard, Linda Silveira, Alain Martel, James L. Douglas, Jon Clardy
Rok vydání:	1984
Předmět:	Chemistry medicine.drug_class Stereochemistry Organic Chemistry Antibiotics X-ray chemistry.chemical_element General Chemistry Sulfur Catalysis Sulfone chemistry.chemical_compound Clavulanic acid medicine Lactam medicine.drug
Zdroj:	Canadian Journal of Chemistry. 62:2282-2286
ISSN:	1480-3291 0008-4042
DOI:	10.1139/v84-388
Popis:	Penems 5 were converted to exocyclic analogs 6 and 10. These served as substrates for conversion to the sulfone 11 and oxopenam 12. None of the products showed any activity as antibiotics or as β-lactamase inhibitors. A single cyrstal X-ray diffraction analysis of compound 6a verified the exocyclic penem structure.
Databáze:	OpenAIRE
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