The role of Epstein-Barr virus in cervical cancer: exploring the immunological mechanisms for production of anti-Estein-Barr virus IgA in high risk women with dysplasia (HUM6P.250)
| Autor: | Rebecca Fisher, Scott Melton, Amelia Ferguson, Hope Oddo, Cruz Velasco-Gonzales, Michael Hagensee |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 194:190.9-190.9 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.194.supp.190.9 |
| Popis: | Human papillomavirus (HPV) alone is a necessary but insufficient cause of cervical cancer due to the high number of infections that spontaneously resolve. We have evidence supporting Epstein-Barr Virus (EBV), a known oncovirus implicated in several cancer types, as a co-factor for cervical disease in HIV+ women. Longitudinal analysis of ELISA data from 453 serum samples, collected over a five year time period from 89 HIV+ women, indicated IgA, but not IgG, against EBV viral capsid antigen (VCA) predicted cervical dysplasia. Sera were also tested for IgG and IgA against HPV16,18 L1 protein and EBV nuclear antigen-1, but no predictive value was observed for these additional targets. Measures of HIV disease control, HIV viral load and CD4 T cell count, were also not predictive of dysplasia. Multivariate models indicated that HPV IgG status did not alter the significance of the EBV VCA IgA prediction. Cervical EBV DNA detection suggests local EBV infection; however, cervical Ab responses are generally IgG. The repetitive structure of the EBV capsid may trigger T cell independent Abs, but the longevity of IgA detection opposes this notion. We hypothesize EBV in the cervix may result in formation of lymphoid-like follicles, as seen in cervicitis, for Ab production. We are collecting dysplastic cervical tissue to establish the existence and functionality of these structures as well as assessing for molecules influencing IgA class switching, such as CXCL-13, BAFF and APRIL. |
| Databáze: | OpenAIRE |
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