ChemInform Abstract: Synthesis of (R,R) and (S,S) Bicyclo(3.3.0)octane-2,6-dione. Interactions Between Non-Conjugated Chromophores

Autor:	André Rassat, Joëlle Pérard-Viret
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Bicyclic molecule Yield (chemistry) Diol Resolution (electron density) General Medicine Enantiomer Chromophore Conjugated system Medicinal chemistry Octane
Zdroj:	ChemInform. 25
ISSN:	0931-7597
DOI:	10.1002/chin.199421105
Popis:	Optically pure bicyclo[3.3.0]octane-2,6-dione is easily obtained with a yield of 4% for each enantiomer from 1,5-cyclooctadiene in 5 steps, by resolution of the intermediate diol with menthyloxyacetic acid. Its CD is 60% larger than twice the CD of a corresponding monoketone indicating interactions between non-conjugated chromophores.
Databáze:	OpenAIRE
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