Stereoselective Synthesis of Novel Aristeromycin Analogues as Potential Antiviral Agents

Autor:	Honoré Monti, Gérard Audran, Paul Brémond, Erik De Clercq
Rok vydání:	2008
Předmět:	biology Chemistry Stereochemistry Organic Chemistry Moderate activity biology.organism_classification Catalysis Nucleobase chemistry.chemical_compound Enantiopure drug Vesicular stomatitis virus Stereoselectivity Trifluoromethanesulfonate Derivative (chemistry)
Zdroj:	Synthesis. 2008:3253-3260
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0028-1083146
Popis:	A series of 3'-methyl-branched and purine-modified analogues of aristeromycin were synthesized via the SN 2 displacement of a key triflate, which was prepared from a readily available enantiopure building block in eight steps. The synthesized compounds were evaluated as potential antiviral agents against important viruses. Only the 2,6-diaminopurine derivative exhibited moderate activity against vesicular stomatitis virus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d0acb39de9d6115c25215e02d589354a https://doi.org/10.1055/s-0028-1083146 Zobrazit plný text záznamu