A Mechanistic Study of the Hydrolytic Stability of Poly(2-(dimethylamino)ethyl methacrylate)

Autor:	Wim E. Hennink, M.J. van Steenbergen, O.A.G.J. van der Houwen, Nicolaas J. Zuidam, Willy J. M. Underberg, P. Van De Wetering
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Aqueous solution Polymers and Plastics Organic Chemistry Kinetics Polymer Methacrylate Inorganic Chemistry Hydrolysis chemistry.chemical_compound Monomer Reaction rate constant chemistry Polymer chemistry Materials Chemistry Chemical decomposition
Zdroj:	Macromolecules. 31:8063-8068
ISSN:	1520-5835 0024-9297
DOI:	10.1021/ma980689g
Popis:	The hydrolytic stability of poly(2-(dimethylamino)ethyl methacrylate) was investigated and compared with the stability of its monomer 2-(dimethylamino)ethyl methacrylate (DMAEMA), with 2-(dimethylamino)ethyl isobutyrate (DMAEIB), representing the repeating unit in the polymer, and with the related 3-(dimethylamino)propyl methacrylate (DMAPMA) (H0/pH range −0.5 to +12, at 37 °C, in aqueous solution). At pH pKa) no differences in stability between the compounds were found. P(DMAEMA), either in its free form or complexed to DNA, was substantially more stable to hydrolytic degradation than DMAEMA and DMAEIB. Fluorescence measurements performed with a copo...
Databáze:	OpenAIRE
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