| Autor: |
Viviani Mendes de Almeida, Daiane F Engel, Mayra Fernanda Ricci, Clênio Silva Cruz, Icaro Santos Lopes, Daniele Almeida Alves, Mirna d’ Auriol, João Magalhães, Giuliana S. Zuccoli, Bradley Joseph Smith, Victor Corasolla Carregari, Elayne Cristina Machado, Victor M. Rocha, Toniana G. Carvalho, Larisse de Souza Barbosa Lacerda, Jordane C. Pimenta, Izabela Galvão, Mariana Aganetti Silva, Erika da Silva Rosa, Geovanni Dantas Cassali, Cristiana C. Garcia, Mauro Martins Teixeira, Leiliane Coelho, Fabiola Mara Ribeiro, Flaviano S. Martins, Rafael Simone Saia, Vivian Vasconcelos Costa, Daniel Martins-de-Souza, João T. Marques, Eric R. G. R. Aguiar, Angelica T. Vieira |
| Rok vydání: |
2023 |
| Popis: |
Long-term sequelae after Coronavirus disease (COVID)-19 are frequent and of major concern. SARS-CoV-2 infection affects the host's gut microbiota, which is linked with disease severity in patients with COVID-19. We report here that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with antibiotic-resistance phenotype compared to healthy controls. Additionally, short-chain fatty acids (SCFA) levels were reduced in their feces. Fecal transplant from post-COVID subjects to germ-free mice led to lung inflammation and worst outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. Transplanted mice also had poorer cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection in the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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