Tissue response to biomaterials used for staple-line reinforcement in lung resection
| Autor: | Cecil C. Vaughn, Paul L. Vaughn, Paul Sawyer, Melanie Manning, Dena Anderson, Leonard Roseman, Thomas J. Herbst |
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| Rok vydání: | 1998 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Lung Polytetrafluoroethylene business.industry medicine.medical_treatment Biomaterial Connective tissue General Medicine Resorption Pneumonectomy chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Pericardium Surgery Lung volumes Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 13:259-265 |
| ISSN: | 1873-734X 1010-7940 |
| DOI: | 10.1016/s1010-7940(98)00012-8 |
| Popis: | Objective: A study in a canine model of lung-reduction surgery evaluated the tissue response to polytetrafluoroethylene (ePTFE) and bovine pericardium (BP) used for staple-line reinforcement. Methods: In each of ten dogs, BP was placed in one lung and ePTFE in the other. The implants were retrieved at 30, 95, or 167 days after implantation and studied histologically. The connective tissue covering the implants was measured and analysis of variance was used to compare results with the two materials. Results: At 30 days, the BP specimens showed focal chronic inflammation and thin tissue coverage, whereas the ePTFE specimens had no focal inflammation and thick tissue coverage. At 95 and 167 days, the inflammation in the BP specimens had resolved, but tissue coverage remained minimal, and there was no resorption of the BP. In the ePTFE specimens, tissue coverage had increased. Analysis of variance comparing representative tissue specimens showed that the tissue encapsulating the ePTFE was significantly thicker than that surrounding the BP (PB0.0001). No air leaks, staple-line disruptions, or infections occurred in the study. Conclusions: Neither ePTFE nor BP is resorbable. Both materials have been used successfully, without resultant infections, for clinical staple-line reinforcement. The more favorable tissue response to ePTFE observed in this study may have clinical ramifications. Comparative clinical studies of the two materials are needed. © 1998 Elsevier Science B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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