The Progenitor Zone of the Ventral Medial Ganglionic Eminence Requires Nkx2-1 to Generate Most of the Globus Pallidus But Few Neocortical Interneurons
| Autor: | John L.R. Rubenstein, Pierre Flandin, Shioko Kimura |
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| Rok vydání: | 2010 |
| Předmět: |
endocrine system
Neocortex biology Ganglionic eminence Cerebrum musculoskeletal neural and ocular physiology General Neuroscience Neurogenesis Medium spiny neuron nervous system diseases Globus pallidus medicine.anatomical_structure nervous system embryonic structures biology.protein medicine Cholinergic neuron Neuroscience Parvalbumin |
| Zdroj: | The Journal of Neuroscience. 30:2812-2823 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.4228-09.2010 |
| Popis: | We show that most globus pallidus neurons, but very few neocortical interneurons, are generated from the ventral medial ganglionic eminence and dorsal preoptic area based on fate mapping using an Shh-Cre allele. The Shh-expressing subpallial lineage produces parvalbumin+GABAergic neurons, ChAT+cholinergic neurons, and oligodendrocytes. Loss of Nkx2-1 function from the Shh-expressing domain eliminated most globus pallidus neurons, whereas most cortical and striatal interneurons continued to be generated, except for striatal cholinergic neurons. Finally, our analysis provided evidence for a novel cellular component (Nkx2-1−;Npas1+) of the globus pallidus. |
| Databáze: | OpenAIRE |
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