| Autor: |
Venugopal Ruby, Sengupta P, Singh Gautam Kumar, Tripathy Durga Madhab, Vashisht Deepak, Agarwal Kriti, Baveja Sukriti |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Journal of Dermatology & Cosmetology. 2 |
| ISSN: |
2574-9943 |
| DOI: |
10.15406/jdc.2018.02.00091 |
| Popis: |
Minocycline is a tetracycline derivative that inhibits growth of Mycobacterium leprae it is used as part of modified Multi Drug Therapy MDT in Hansen s disease Pigmentation is a very common benign side effect of the drug and can be seen in inflammatory as well as non inflammatory skin sclera teeth gums pinnae and scar tissue We report a case of Hansen s disease Borderline Lepromatous with minocycline induced hyperpigmentation specifically over multiple lepromatous patches Although clofazimine is more commonly responsible for pigmentation in Hansen s disease there is paucity of data implicating minocycline as a cause This patient presented with hyperpigmentation of leprosy patches both at sun exposed and protected sites Histopathology of these patches revealed foamy histiocytes and numerous Acid Fast Bacilli AFB along with multiple melanophages unlike clofazimine pigmentation in which there is deposition of ceroid lipofuschin and not melanin On stoppage of minocycline the pigmentation is gradually resolving |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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