Specific Features of Phase Transfer Catalytic Glycosylation of 2-Mercaptobenzimidazole
| Autor: | V. O. Kur’yanov, T. A. Chupakhina |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Glycosylation 010405 organic chemistry Hydride Organic Chemistry Mass spectrometry 01 natural sciences Biochemistry Combinatorial chemistry Chloride 0104 chemical sciences Catalysis 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Phase (matter) Anhydrous medicine Methylene medicine.drug |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 46:1285-1288 |
| ISSN: | 1608-330X 1068-1620 |
| Popis: | The reaction of 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl chloride with 2‑mercaptobenzimidazole under conditions of the phase transfer catalysis was studied and specific features of the phase transfer process were evaluated. It was found that the corresponding N- and S-β-D-glucosaminides were the major glucosaminylation products. Glucosaminylation of 2-mercaptobenzimidazole in an anhydrous methylene chloride–sodium hydride phase transfer catalytic system was shown to proceed regiospecifically. The structures of the synthesized compounds were characterized using 1H NMR spectroscopy and mass spectrometry. |
| Databáze: | OpenAIRE |
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