| Popis: |
A retrosynthetic analysis using the computer program LHASA of the promising antitumor agent taxol (1) is described, which resulted in a synthetic route with the following key steps: an intramolecular Diels-Alder reaction generating the AB rings, and the coupling reactions of the required diene and dienophile with a CD-ring fragment. The feasibility of the route is studied by comparing the LHASA analysis with related chemistry from the literature. Finally, a critical discussion about the usability of the LHASA program for the planning of complex organic molecules is given.] |
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