ChemInform Abstract: Structural Elucidation of Trikoningins KA and KB, Peptaibols from Trichoderma koningii
| Autor: | Isabelle Vuidepot, Catherine Auvin-Guette, Sylvie Rebuffat, Marcel Massias, Bernard Bodo |
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| Rok vydání: | 2010 |
| Předmět: |
chemistry.chemical_classification
Trichoderma koningii biology Strain (chemistry) medicine.drug_class Antibiotics Peptide General Medicine biology.organism_classification Mass spectrometry medicine.disease_cause Molecular biology chemistry Permeability (electromagnetism) Staphylococcus aureus medicine |
| Zdroj: | ChemInform. 24 |
| ISSN: | 0931-7597 |
| DOI: | 10.1002/chin.199318307 |
| Popis: | A Trichoderma koningii strain collected in Uruguay produced two antibiotic membrane-active peptidic groups, the trikoningins KA and KB, from which the main components KA V, KB I and KB II were purified. The peptide sequences were elucidated by FAB mass spectrometry and high-field NMR experiments. KA V was a nonadecapeptaibol, whereas KB I and KB II were two 11-residue lipopeptaibols. They all displayed antibiotic activity against Staphylococcus aureus. Their membrane-modifying properties were examined by following the leakage of liposome-entrapped carboxyfluorescein. KA V induced similar permeability modifications to those exhibited by known 19-residue peptaibols, while the KB I and KB II activities were weaker. |
| Databáze: | OpenAIRE |
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