NIR responsive AuNR/pNIPAM/PEGDA inverse opal hydrogel microcarriers for controllable drug delivery

Autor:	Xiaoyan Sun, Baofen Ye, Ling-Zi Liu, Zhengyu Yan
Rok vydání:	2021
Předmět:	Chemistry technology industry and agriculture Microcarrier Nanotechnology General Chemistry Colloidal crystal Photothermal therapy Catalysis Drug delivery Materials Chemistry Drug release Nanorod Thermo responsive Heating effect
Zdroj:	New Journal of Chemistry. 45:7893-7899
ISSN:	1369-9261 1144-0546
DOI:	10.1039/d0nj06289h
Popis:	Particle-based delivery systems have emerged as a powerful platform in controlled drug release. In the present study, we developed a new inverse opal hydrogel microcarrier system composed of gold nanorods (AuNRs) for near-infrared light (NIR) activated drug delivery. AuNRs with a desired aspect ratio were prepared by a seed-mediated growth method. The inverse opal hydrogel microcarriers composited with AuNRs were synthesized by negatively replicating silica colloidal crystal beads (SCCBs). The NIR-thermo response of the microcarriers was due to the NIR photothermal heating effect of AuNRs and the thermo responsive volume transition of poly(N-isopropylacrylamide) (pNIPAM) hydrogel. It was found that the NIR-controlled reversible shrinking response of the microcarriers was ideal for the controllable drug release with real-time self-reporting color indication.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d09517664f9e1e695e1d5dad286e459b https://doi.org/10.1039/d0nj06289h Zobrazit plný text záznamu