Biological impact of lipophilic sediment extracts from the Kafue River, Zambia, in microinjected rainbow trout yolk-sac fry and chick embryo livers exposed in vitro

Autor:	L. Norrgren, B. Brunström, M. Engwall, M. Mwase
Rok vydání:	1998
Předmět:	animal structures Ecology Management Monitoring Policy and Law Aquatic Science
Zdroj:	Aquatic Ecosystem Health & Management. 1:91-99
ISSN:	1539-4077 1463-4988
DOI:	10.1080/14634989808657008
Popis:	Lipophilic sediment extract originating from the Kafue River, Zambia, was evaluated for toxic potency. Two different bioassays were used. In the first, sediment extracts were injected into newly hatched rainbow trout yolk-sac fry, and in the second chick embryo livers were incubated in vitro in different concentrations of the sediment extract. A dose-dependent ethoxyresofurin-O-deethylase (EROD) induction was recorded in both experiments. Furthermore, various types of intracellular alterations characterized by degenerative and necrotic changes were observed in the hepatocytes of the exposed groups. These findings indicate the presence of EROD inducing dioxin-like lipophilic substances in sediment extracts originating from the Kafue River near the town of Kitwe.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d08e90c7904b5d3edf904653e0448d47 https://doi.org/10.1080/14634989808657008 Zobrazit plný text záznamu