A case of acute lymphocytic leukemia with trismus caused by leukemic cell invasion with internal derangement of the temporomandibular joint

Autor: Kenzaburoh Koga, Masahiko Toyama, Koji Satoh, Goroh Hibi, Takaaki Tsujikawa, Yoshimi Yamamoto
Rok vydání: 1999
Předmět:
Zdroj: Japanese Journal of Oral & Maxillofacial Surgery. 45:700-702
ISSN: 2186-1579
0021-5163
DOI: 10.5794/jjoms.45.700
Popis: A 18-year-old woman was referred to the Department of Oral and Maxillofacial Surgery, Handa City Hospital because of arthralgia of the right temporomandibular joint (TMJ). The patient had a history of right TMJ clicking and limited mouth opening (30 mm). MRI disclosed anterior disc displacement without reduction of the right TMJ. Medication and pumping manipulation had little effect, followed by a gradual reduction in mouth opening. Three months later, she had a mild fever, nasal obstruction, and peripheral paresthesia. CT and MRI demonstrated tumor invasion into the nasopharynx, maxillary sinus, infratemporal fossa, and pterygoid muscles. Examination of a biopsy specimen taken from the upper pharynx revealed a hematogenic tumor. The patient was admitted to the hematology division of Fujita Health University. The diagnosis of acute lymphocytic leukemia was established by examination of the bone marrow aspirate. Induction chemotherapy was initiated according to the JAL SG ALL-93 protocol. The TMJ symptoms resolved with subsequent courses of chemotherapy. On CT and MRI, the tumor disappeared, but mouth opening was limited to 30 mm. Splint therapy and manipulation on every visit were carried out. Two months later, her maximum mouth opening increased to 42 mm. Her clinical course has been favorable without any evidence of recurrence after bone marrow transplantation.
Databáze: OpenAIRE