Antibacterial Surface Coatings from Zinc Oxide Nanoparticles Embedded in Poly(N-isopropylacrylamide) Hydrogel Surface Layers
| Autor: | Alexandros Lappas, Ulrich Jonas, Véronique B. Schwartz, Franck Thétiot, L. Choritz, Katharina Landfester, Sandra Ritz, Sabine Pütz, Renate Förch |
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| Rok vydání: | 2012 |
| Předmět: |
Nanocomposite
Materials science Scanning electron microscope Nanoparticle chemistry.chemical_element Nanotechnology 02 engineering and technology Zinc 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences 3. Good health Electronic Optical and Magnetic Materials Biomaterials chemistry.chemical_compound chemistry Polymer ratio Self-healing hydrogels Electrochemistry Poly(N-isopropylacrylamide) 0210 nano-technology Prepolymer Nuclear chemistry |
| Zdroj: | Advanced Functional Materials. 22:2376-2386 |
| ISSN: | 1616-301X |
| Popis: | Despite multiple research approaches to prevent bacterial colonization on surfaces, device-associated infections are currently responsible for about 50% of nosocomial infections in Europe and signifi cantly increase health care costs, which demands development of advanced antibacterial surface coatings. Here, novel antimicrobial composite materials incorporating zinc oxide nanoparticles (ZnO NP) into biocompatible poly( N -isopropylacrylamide) (PNIPAAm) hydrogel layers are prepared by mixing the PNIPAAm prepolymer with ZnO NP, followed by spin-coating and photocrosslinking. Scanning electron microscopy (SEM) characterization of the composite fi lm morphology reveals a homogeneous distribution of the ZnO NP throughout the fi lm for every applied NP/polymer ratio. The optical properties of the embedded NP are not affected by the matrix as confi rmed by UV-vis spectroscopy. The nanocomposite fi lms exhibit bactericidal behavior towards Escherichia coli (E. coli) for a ZnO concentration as low as ≈ 0.74 μ g cm − 2 (1.33 mmol cm − 3 ), which is determined by inductively coupled plasma optical emission spectrometry. In contrast, the coatings are found to be non-cytotoxic towards a mammalian cell line (NIH/3T3) at bactericidal loadings of ZnO over an extended period of seven days. The differential toxicity of the ZnO/hydrogel nanocomposite thin fi lms between bacterial and cellular species qualifi es them as promising candidates for novel biomedical device coatings. |
| Databáze: | OpenAIRE |
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