Morin hydrate
| Autor: | Yim Ping Wong, Tim-Tak Kwok, H.C. Chan, L.D.S. Kok, Tai-Wing Wu, Kwok-Pui Fung |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Chemistry medicine.medical_treatment Mitomycin C General Medicine Pharmacology medicine.disease General Biochemistry Genetics and Molecular Biology Umbilical vein Enzyme Hepatocellular carcinoma Toxicity medicine Doxorubicin General Pharmacology Toxicology and Pharmaceutics Cytotoxicity medicine.drug |
| Zdroj: | Life Sciences. 67:91-99 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(00)00605-6 |
| Popis: | The co-incubation of morin hydrate with either doxorubicin or mitomycin C could minimize the toxicity of these anti-tumor drugs on cardiovascular cells, such as red blood cells, human umbilical vein endothelial cells (ECV304) and primary mouse cardiomyocytes, whereas morin hydrate did not lower the cytotoxicity of the drugs on human hepatocellular carcinoma cells (HepG2). Morin hydrate may not exert its antioxidant effect by enhancing the antioxidant enzymatic activity because it did not cause any induction on the mRNA levels of manganese superoxide dismutase expression in ECV304 cells and HepG2 cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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