| Autor: |
Hong Xue, Taobo Hu, Joseph Chun-Kit Chung, Wai-Kin Mat, Wai-Kuen Ho, Xuejiao Lina Hu |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of Clinical and Surgical Pathology. 2 |
| DOI: |
10.36959/724/313 |
| Popis: |
In conclusion, the occurrences of a wave of forward mutations followed by their reversals were observed in this patient in the process from benign to malignant transformation. Because tumors are driven by mutations, delineating the nature of mutations in the evolution process into malignant cells furnishes the basis for understanding carcinogenesis. In the present study, the analysis of time series samples in both benign and malignant tumor components from the same patient showed a bulk of forward mutations occurring in benign tissue were reversed in its malignancy. The dominance of reverse somatic mutations in the benign to malignant transformation is a cellular mechanism for gaining advantages of cell survival through regulation of the mutation load. The identification of reverse somatic mutations provides a basis for facilitating diagnosis of malignancy. Because this is a single case analysis, more genetic studies are needed to definitively elucidate genomic alterations driving the malignant transformation of OM and its enigma. The similar sequencing analysis of benign looking adjacent tissue should be performed in order to detect genomic changes when benign to malignant tumor transition is suspected. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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