Synthesis, Characterization and Testing of Biological Activity of Some Novel Chalcones Derivatives of Coumarin

Autor:	Chandrashekar P. Pandhurnekar, Himani N. Chopde, Harshal A. Deshpande, Rameshkumar J. Batra
Rok vydání:	2013
Předmět:	Benzaldehyde Chalcone chemistry.chemical_compound chemistry Salicylaldehyde Aryl Proton NMR Infrared spectroscopy General Medicine Piperidine Coumarin Medicinal chemistry
Zdroj:	Chemical Science Transactions. 2:621-627
ISSN:	2278-3318 2278-3458
DOI:	10.7598/cst2013.317
Popis:	In the present communication, we herein report the synthesis of some novel derivatives of coumarin i.e. 3-((2E)-(3-(2-hydroxy-5-((aryl)diazenyl)phenyl)acryloyl)-2H-chromen-2-one (2a-2g). Various aromatic amines and salicylaldehyde in the presence of sodium nitrite and conc. HCl yielded 2-hydroxy-5-((aryl)diazenyl)benzaldehyde (1a-1g). A series of 3-((2E)-(3-(2-hydroxy-5-((aryl)diazenyl) phenyl)acryloyl)-2H-chromen-2-one were synthesized by the reaction of 2-hydroxy-5-((aryl)diazenyl) benzaldehyde and coumarin in presence of ethanol and piperidine. Different analytical techniques such as elemental analysis, IR spectra, H NMR spectra and mass spectra were used to elucidate the structures of all newly synthesized compounds (1a-1g and 2a-2g). The anti-bacterial and anti-fungal activity of newly synthesized chalcone derivatives (2a-2g) were evaluated against different bacterial and fungal stains. Some of these compounds showed promising activity against different stains.
Databáze:	OpenAIRE
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