Platelet Receptor HPA-1 Polymorphism of αIIbβ3 and 807 C/T Polymorphism of α2β1 and Buerger's Disease
| Autor: | D. Zelenika, Reiner B. Zotz, Christoph Sucker, L. Ostojic, Robert Loncar, Z. Ostojic |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Buerger's disease
medicine.medical_specialty Pathology Systemic disease business.industry Vascular disease Disease 030204 cardiovascular system & hematology medicine.disease Gastroenterology Thrombosis Pathogenesis 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine Platelet Myocardial infarction Cardiology and Cardiovascular Medicine business |
| Zdroj: | Angiology. 58:169-174 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/0003319707300352 |
| Popis: | Thromboangiitis obliterans or Buerger's disease is an episodic and segmental inflammatory and thrombotic process of the medium and small arteries of the lower extremities. Even though the disease was described 90 years ago, the etiopathogenesis is still under consideration. Afflicted patients are mostly young male cigarette smokers without signs of atherosclerosis or other risk factors for peripheral arterial occlusive disease. This indicates that hereditary thrombophilic factors could play a role in the etiopathogenesis. Recently, increasing evidence shows that platelet receptor polymorphisms (HPA-1 polymorphism of β3 subunit of αIIbβ3 and 807 C/T polymorphism α2β1) are associated with early onset of arterial thrombosis (myocardial infarction, stroke). This case-control study was designed to assess whether the 807 C/T polymorphism or the HPA-1 polymorphism is involved in the pathogenesis of Buerger's disease or has any influence on the clinical course of Buerger's disease. Eighteen patients with Buerger's disease and 81 (sex and age matched) healthy control subjects (mean age 44 ± 10 vs 45 8 years, respectively) were genotyped for platelet receptor HPA-1 and GPIa 807 C/T polymorphism. The gene frequency of HPA-1 and GPIa 807 C/T polymorphisms was identical in both groups. Prevalence of hetero- and homozygous carriers of the HPA-1b allel (1a1b and 1b1b genotype) as well as the prevalence of the 807 C/T and 807 T/T carriers did not differ significantly between the two groups, p >0.05. The grade of clinical disease manifestation as well as disease progression did not reveal any significant relationship with HPA-1 and 807 C/T polymorphisms. A relationship between the age at onset of the disease and HPA-1 polymorphism was not found. Otherwise analysis of the GPIa 807 C/T platelet receptor polymorphism showed that the average age of patients who are carriers of the T allele at early onset of disease was 32 ± 6 years (range 27—48 years) compared to 42 ± 6 years (range 34—53 years) of the C/C carriers (p |
| Databáze: | OpenAIRE |
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