CD4 + T cells regulate glucose homeostasis independent of adipose tissue dysfunction in mice

Autor: Georg Brinker, Julia Braune, Lilli Arndt, Constance Hobusch, Martin Gericke, Andreas Lindhorst, Janine Froeba, Ingo Bechmann
Rok vydání: 2021
Předmět:
Zdroj: European Journal of Immunology. 51:1399-1411
ISSN: 1521-4141
0014-2980
Popis: Obesity is frequently associated with a chronic low-grade inflammation in the adipose tissue (AT) and impaired glucose homeostasis. Adipose tissue macrophages (ATMs) have been shown to accumulate in the inflamed AT either by means of recruitment from the blood or local proliferation. ATM proliferation and activation can be stimulated by TH2 cytokines, such as IL-4 and IL-13, suggesting involvement of CD4-positive T cells in ATM proliferation and activation. Furthermore, several studies have associated T cells to alterations in glucose metabolism. Therefore, we sought to examine a direct impact of CD4-positive T cells on ATM activation, ATM proliferation and glucose homeostasis using an in vivo depletion model. Surprisingly, CD4 depletion did not affect ATM activation, ATM proliferation or insulin sensitivity. However, CD4 depletion led to a significant improvement of glucose tolerance. In line with this, we found moderate disturbances in pancreatic endocrine function following CD4 depletion. Hence, our data suggest that the effect on glucose metabolism observed after CD4 depletion might be mediated by organs other than AT and independent of AT inflammation. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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