Serum IL-4, IL-12, IL-13, IL-27, and IL-33 levels in active and inactive ocular Behcet’s disease
| Autor: | Orhan Ayyildiz, Fatih Mehmet Türkcü, Alparslan Şahin, Abdullah Kürşat Cingü, Serdar Aktas |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
business.industry
medicine.medical_treatment Interleukin Disease Behcet's disease medicine.disease Interleukin 33 03 medical and health sciences Ophthalmology 0302 clinical medicine Cytokine Interleukin 13 Immunology 030221 ophthalmology & optometry Interleukin 12 medicine business 030217 neurology & neurosurgery Interleukin 4 |
| Zdroj: | International Ophthalmology. 40:3441-3451 |
| ISSN: | 1573-2630 0165-5701 |
| Popis: | To investigate serum levels of interleukin (IL)-12 (Th1 cytokine), IL-27 (an immunomodulatory cytokine), IL-4 (suppressor of Th1-cell growth), IL-13 (a stimulatory signal for Th2 cytokines), and IL-33 (an epithelial cell-derived cytokine) and their relations with the disease activity in Behcet’s Disease (BD). Four groups, each composed of 20 participants were enrolled in the study; active ocular BD (Group-A), ocular BD in remission (Group-B), nonocular BD in remission (Group-C) and healthy controls (Group-D). IL levels were compared between the study groups and their correlation with the disease activity parameters were analyzed. IL-13 and IL-33 were higher in Group-A. IL-27 was lower in all BD groups. Additionally, IL-13 and IL-33 levels were positively correlated with disease activity parameters. These findings show Th2 dominance in the active phase of BD. Besides, decreased levels of IL-27, and presumably, its protective anti-inflammatory effect in all study groups may exert a new pathologic finding in BD. |
| Databáze: | OpenAIRE |
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