Royal jelly inhibitedN-acetylation and metabolism of 2-aminofluorene in human liver tumor cells (J5)

Autor:	Kwong C. Cheng, Fu S. Yu, Jing G. Chung, Chun S. Yu, Feng T. Yeh
Rok vydání:	2005
Předmět:	food.ingredient Human liver Health Toxicology and Mutagenesis N-acetyltransferase Tumor cells Metabolism Biology Pollution High-performance liquid chromatography food Biochemistry Acetylation Royal jelly N acetylation Environmental Chemistry
Zdroj:	Toxicological & Environmental Chemistry. 87:83-90
ISSN:	1029-0486 0277-2248
DOI:	10.1080/02772240410001715502
Popis:	The present study was carried out to evaluate the question of whether or not royal jelly affects N-acetylation and metabolism of 2-aminofluorene (2-AF) in the human liver tumor cell line (J 5). N-acetylation and metabolism of 2-AF in intact J5 cells was determined by using high performance liquid chromatography for the amounts of acetylated and nonacetylated 2-AF and profile of 2-AF metabolism. The results indicated that royal jelly displayed a dose-dependent inhibition of N-acetylation of 2-AF in J5 cells. Royal jelly also decreased the profile of 2-AF metabolites in J5 cells. This report is the first demonstration which showed that royal jelly affects N-acetylation of 2-AF in human liver tumor cells (J5).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d04b95244f51cc1beca252305cfc56df https://doi.org/10.1080/02772240410001715502 Zobrazit plný text záznamu