Sleep deprivation with sleep phase advance in treatment-resistant depression therapy in relation to features of circadian rhythm and temperament – a pilot study
| Autor: | Janusz K. Rybakowski, Ewa Ferensztajn-Rochowiak, Maria Chłopocka-Woźniak, Ewa Kurczewska |
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| Rok vydání: | 2019 |
| Předmět: |
Cultural Studies
business.industry media_common.quotation_subject Religious studies medicine.disease 030227 psychiatry 03 medical and health sciences Sleep deprivation 0302 clinical medicine Medicine Sleep phase Temperament Circadian rhythm medicine.symptom business Treatment-resistant depression 030217 neurology & neurosurgery Clinical psychology media_common |
| Zdroj: | Pharmacotherapy in Psychiatry and Neurology. 34:249-262 |
| ISSN: | 1234-8279 |
| Popis: | Objectives. The efficacy of pharmacotherapy augmentation by total sleep deprivation (TSD) with sleep phase advance (SPA) was evaluated in patients with treatment-resistant depression (TRD). The study examined the relationship between chronotype, affective temperaments and clinical improvement resulting from the treatment. Material and methods. The study group comprised of 30 persons with treatment-resistant unipolar (n = 15) or bipolar (n = 15) depression aged 52 ± 12 years (17 women and 13 men). TSD and three consecutive nights with SPA were used during pharmacotherapy. Severity of depression was determined using the Hamilton Depression Rating Scale (HDRS). All patients were assessed using the Composite Scale of Morningness (CSM) and Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A). Results. Clinical response, defined as a reduction in the severity of depression by ≥ 50% in HDRS compared to the baseline score, lasting until the end of the study (14 days), was obtained in 16 out of 30 patients with TRD. There was found no significant correlation between clinical improvement, chronotype and affective temperaments. Conclusions. TSD with SPA proved to be an effective method of pharmacotherapy augmentation in over half of the patients with TRD. The relationship between chronotype, affective temperaments and the clinical response to chronotherapy of depression requires further research. |
| Databáze: | OpenAIRE |
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