Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO
Autor: | David Matuskey, Ania M. Jastreboff, Patrick D. Worhunsky, Robert T. Malison, Richard E. Carson, Kelly P. Cosgrove, Lauren Kantrovitz, Marc N. Potenza, Gustavo A. Angarita, Jean-Dominique Gallezot, Edward C. Gaiser, Brian Pittman |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Agonist medicine.medical_specialty medicine.drug_class Substantia nigra 03 medical and health sciences 0302 clinical medicine Dopamine Dopamine receptor D2 Internal medicine medicine Pharmacology business.industry Ventral striatum Antagonist Ventral tegmental area Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Endocrinology Brain stimulation reward Psychology Nuclear medicine business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Neuropsychopharmacology. 41:3042-3050 |
ISSN: | 1740-634X 0893-133X |
Popis: | Most prior work with positron emission tomography (PET) dopamine subtype 2/3 receptor (D2/3R) non-selective antagonist tracers suggests that obese (OB) individuals exhibit lower D2/3Rs when compared with normal weight (NW) individuals. A D3-preferring D2/3R agonist tracer, [11C](+)PHNO, has demonstrated that body mass index (BMI) was positively associated with D2/3R availability within striatal reward regions. To date, OB individuals have not been studied with [11C](+)PHNO. We assessed D2/3R availability in striatal and extrastriatal reward regions in 14 OB and 14 age- and gender-matched NW individuals with [11C](+)PHNO PET utilizing a high-resolution research tomograph. Additionally, in regions where group D2/3R differences were observed, secondary analyses of 42 individuals that constituted an overweight cohort was done to study the linear association between BMI and D2/3R availability in those respective regions. A group-by-brain region interaction effect (F7, 182=2.08, p=0.047) was observed. Post hoc analyses revealed that OB individuals exhibited higher tracer binding in D3-rich regions: the substantia nigra/ventral tegmental area (SN/VTA) (+20%; p=0.02), ventral striatum (VST) (+14%; p |
Databáze: | OpenAIRE |
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