Aliphatic ethers of 1-(2,4-dichlorophenyl)-2-(1-H-imidazolyl)ethanol: influence of ramification and/or unsaturation on lipophilicity and antifungal activity

Autor:	R. Caujolle, J. P. Seguela, C. Tournaire‐Arellano, M. D. Linas, J. L. Stigliani, C. Recoche, Marc Payard
Rok vydání:	1998
Předmět:	Pharmacology Steric effects Degree of unsaturation Ethanol Organic Chemistry General Medicine Yeast chemistry.chemical_compound chemistry Drug Discovery Lipophilicity medicine Imidazole Structure–activity relationship Organic chemistry Miconazole medicine.drug
Zdroj:	European Journal of Medicinal Chemistry. 32:1001-1007
ISSN:	0223-5234
Popis:	Summary Ethers of 1-(2,4-dichlorophenyl)-2-(1- H -imidazolyl)ethanol bearing ramified and/or unsaturated chains have been synthesized in order to specify the role of lipophilicity or steric contributions on antifungal activity against yeast for miconazole-like structures. The presence of ramifications on aliphatic chains (between 4 and 7 carbons) or unsaturation at the end, increases antifungal activity. For these compounds, lipophilicity seems to be counterbalanced by steric contributions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d04456e14014d93e3ab61e85c1ab884a https://doi.org/10.1016/s0223-5234(97)89644-4 Zobrazit plný text záznamu Full Text from ScienceDirect