| Popis: |
Background Despite a large number of clinical trials devoted to the subject, there are currently several controversial ideas about the interdependence between allergic diseases and parasitic invasions. This study analyses the dependence between the frequency of clinical manifestations of allergy (bronchial asthma, pollinosis, allergic rhinitis, atopic dermatitis) and the rate of sustained remission in 18-year-old adolescents who had been regularly examined due to their bronchial asthma since early childhood. The aim of this study was to compare catamnestic data collected about children with bronchial asthma with regard to the presence or absence of concomitant helminthes and protozoa invasions in childhood. Materials and methods Follow-up data was collected about 90 adolescents who had been treated for mild to moderate bronchial asthma in childhood. During the follow-up period, all the children had been regularly screened for extensive helminthic infestations (enterobiasis, ascaridiasis) and lambliasis. The patients were grouped by invasion in the following way: Group 1 – children who had never had a single episode of invasion during the follow-up period (48 patients), and Group 2 – children who had been diagnosed with and successfully treated for enterobiasis, ascaridiasis, or lambliasis (42 patients). The catamnestic analysis also assessed the incidence of skin and respiratory manifestations of allergy, and compared the frequency of remission that lasted less than 3 years, from 3 to 6 years, from 6 to 12 years, and for over 12 years. Results Among all the children with invasions, the first episo-de of bronchial obstruction was the onset of allergic pathology in half of the cases; at the same time, the same was true only for 15% of the children without invasions. Despite therapy against bronchial asthma, a sustained long-lasting remission of respiratory symptoms was absent in 44±6% children of Group 1 and in 43±7% (p Conclusions The collected follow-up data suggest that respiratory symptoms developing alongside immunology shifts triggered by a parasitic invasion are, as a rule, considered as onset of bronchial asthma. However, if the condition was diagnosed early in preschool children, and adequate antiparasitic therapy was given, about 15% of the patients had no clinical symptoms of allergic inflammation later in life. |
