| Popis: |
Publisher Summary This chapter discusses the analytical profile of ceftazidime. Ceftazidime pentahydrate 1.16 g is approximately equivalent to 1 g of anhydrous ceftazidime. The appearance is white to off white powder in color and changes to dark brown, and decomposes at 135 to 137oC. The drug has the solubility of .5 mg/ml in water and less than 1 mg/ml in alcohol. Drug is highly stable to hydrolysis by most β-lactamases produced by Gram-negative and Gram-positive bacteria. Drug for injection is essentially stable in the dry state and can be stored at room temperature, but should be protected from light. The X-ray diffraction pattern of ceftazidime was determined on a Philips X-ray diffraction spectrosoniometer, fitted with PW 1730 generator. The chapter also discusses that Ceftazidime, synthesized by the reaction of nitrous acid with ethylacetoacetate to produce oxime, is administered by injection as the sodium salt. It is widely distributed in body tissues and fluids including bone, synovial fluid, heart, bile, sputum, and aqueous humor; the therapeutic concentrations are achieved in the cerebrospinal fluid when the meninges are inflamed; it diffuses across the placenta and is excreted in breast milk. |
