| Autor: |
M Anitha Rani, P Solairaj, Subbramanian L, T Rajasekaran, M Ramanathan |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of Drug Delivery and Therapeutics. 9:31-37 |
| ISSN: |
2250-1177 |
| Popis: |
This study concluded that Metformin HCl was successfully prepared as a liposomal drug delivery system by using two different techniques such as physical dispersion method and ether injection method. In this liposomes preparations, cholesterol ratio was constant and soya lecithin concentrations were gradually increased (like 1:1, 1:2 and 1:3). The liposomes prepared by physical dispersion method showed better percentage drug entrapment when compared with ether injection method. The morphological characters of prepared liposomes were determined with the help of optical microscope. The particle size was analyzed by Malven particle size analyzer. The results of the particle size showed, when the concentration of soya lecithin was increased the size of the particle was reduced. The in vitro release showed that as the concentration of soya lecithin was increased the release rate of drug was retarded. Among the two methods ether injection method showed prolonged action when compared to physical dispersion method. The stability studies for all the formulations were performed by keeping the formulations at two different temperatures 4oC±2oC and 25oC±2oC for a period of 30 days. After the stability period the formulations were tested for morphological analysis, percentage drug entrapment and in vitro drug release and compared with before stability study. There was no change in morphological characters at 4oC±2oC, but there was a slight reduced in particles size at 25oC±2oC. The percentage drug entrapment was reduced in all the formulations at both the conditions. The in vitro drug release was reduced for all the formulations. Liposomes prepared by physical dispersion method showed better stability compared with ether injection method. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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