Rh(III)-catalyzed C–H activation-desymmetrization of diazabicycles using enol as directing group: A straightforward approach to difunctionalized cyclopentenes

Autor:	Yu He, Lisha Li, Yanan Tu, Tingting Wen, Tianbo Shang, Yan Zhang, Shanshan Wang, Dan Lin
Rok vydání:	2018
Předmět:	010405 organic chemistry Chemistry Organic Chemistry Substrate (chemistry) 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Desymmetrization Enol 0104 chemical sciences Catalysis chemistry.chemical_compound Atom economy Drug Discovery
Zdroj:	Tetrahedron Letters. 59:1394-1397
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2018.02.063
Popis:	A Rh(III)-catalyzed C–H activation-desymmetrization of diazabicycles with o-vinylphenols as an efficient approach to alkenyl-substituted aminocyclopentenes is reported. This protocol represents another classic example for direct C–H activation of terminal alkenes using enol as directing group. The reaction features the ease of the preparation of starting materials, fast and high efficiency, broad substrate scope and 100% atom economy, thus provides a valuable entry to synthesize novel substituted cyclopentenes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d03c287d33ff1c212a343b4e8f02931f https://doi.org/10.1016/j.tetlet.2018.02.063 Zobrazit plný text záznamu Full Text from ScienceDirect