Changes in the background activity of neurons of the central gray substance when serotonin is applied to it or its synthesis is blocked

Autor: V. A. Yakhnitsa, A. I. Pilyavskii, Yu. P. Limanskii, N. V. Bulgakova
Rok vydání: 1992
Předmět:
Zdroj: Neurophysiology. 24:107-114
ISSN: 1573-9007
0090-2977
DOI: 10.1007/bf01893029
Popis: The changes in the background activity (BA) of neurons of the central gray substance upon the iontophoretic application of serotonin (ST) to them in a concentration of 1·10−4 mole/liter, and following the blockage of its synthesis by pchlorophenylalanine (PCPA), were investigated in hexenal-anesthetized rats. The application of ST led to changes in the BA only in group III neurons, in which the BA was distinguished by continuous action potential generation. The application of ST elicited an increase in the frequency of the BA in 21.2% of such neurons, suppression in 45.5%, and the BA remained unchanged in 33.3% of the units. The identified changes in the BA in these neurons coincided with those which arose as the result of stimulation of the monoaminergic structures. When the application of ST was combined with stimulation of the locus coeruleus (LC), the substantia nigra (SN), and the nucleus raphe magnus (NRM), the suppression of the BA was intensified; however, when the LS and the SN were stimulated, the suppression was more pronounced than with stimulation of the NRM. The intensity of the suppressant effect of the NRM decreased after preliminary administration of PCPA, but it did not disappear completely, and the influences elicited by the LS and the SN intensified. The mechanisms of the serotoninergic control of the activity of the neurons of the central gray substance are discussed.
Databáze: OpenAIRE
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