Aterm Pregnancy Woman with Human Immunodeficiency Virus Infection and Antiretroviral Therapy as Risk Factor of High Caspase-3 Expression in Placenta

Autor: Denni Prasetyo, I Wayan Artana Putra, Tjokorda G. A. Suwardewa, I Nyoman Hariyasa Sanjaya, Anom Suardika, I Gde Sastra Winata
Rok vydání: 2022
Zdroj: European Journal of Medical and Health Sciences. 4:42-45
ISSN: 2593-8339
DOI: 10.24018/ejmed.2022.4.3.1324
Popis: Aim: To determine whether term pregnant women with human immunodeficiency virus infection who received antiretroviral therapy have a high Caspase-3 expression in the placenta. Methods: This cross-sectional analytical study was conducted at Sanglah General Hospital, Denpasar, and affiliated hospitals. Subjects were termed pregnant women with HIV (+) who received a minimum of six months of antiretroviral therapy as a risk group and pregnant women with HIV (-) as a non-risk group. Caspase-3 expression was assessed by immunohistochemical examination of placental tissue. The cut-off value for caspase-3 levels was determined by constructing a receiver operating characteristics (ROC) curve. The difference in proportion was assessed by the chi-square test, and the prevalence ratio (PR) was reported. The significance of this study was p
Databáze: OpenAIRE