The association between isolated fetal echogenic cardiac foci on second-trimester ultrasound scan and trisomy 21 in low-risk unselected women

Autor: S. Salgia, E. Havutcu, R. Nicholl, P. Adinkra, R. F. Lamont
Rok vydání: 2004
Předmět:
Zdroj: Ultrasound in Obstetrics and Gynecology. 23:346-351
ISSN: 0960-7692
DOI: 10.1002/uog.1018
Popis: Objectives To determine the prevalence of and the association between trisomy 21 and isolated fetal echogenic cardiac foci (FECF) identified in the second trimester in an unselected low-risk population. Methods All cases with isolated FECF were collected by reviewing the antenatal ultrasound database for 3 consecutive years. In order to include all trisomy 21 cases for the same period, the regional cytogenetics database and pediatric databases were examined. A 2 × 2-table analysis was performed to establish the sensitivity, specificity and positive and negative predictive values of isolated FECF as a screening test for trisomy 21 in a low-risk unselected population. Results In the 3-year period of the study the total number of deliveries was 11 105, of which 10 769 (97%) had a routine detailed anomaly scan between 16 and 24 weeks' gestation. There were 311 cases (2.9%) of isolated FECF. Among these there was only one case (0.3%) of trisomy 21. In the same period, the total number of trisomy 21 cases was 14. Accordingly, the sensitivity of isolated FECF for detecting trisomy 21 was 7.1% and the specificity was 97.1%. Positive and negative predictive values of FECF were 0.3% and 99.9%, respectively. Conclusion In an otherwise healthy pregnancy, the finding of isolated FECF on a routine second-trimester anomaly scan is normal and should not be considered as a risk factor for trisomy 21 in an unselected low-risk population. Copyright © 2004 ISUOG. Published by John Wiley & Sons, Ltd.
Databáze: OpenAIRE
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