First synthesis and determination of the absolute stereochemistry of iso-cladospolide-B and cladospolides-B and C

Autor:	J. Janardhan Reddy, G. V. M. Sharma, K. Laxmi Reddy
Rok vydání:	2006
Předmět:	Stereochemistry Chemistry Organic Chemistry Drug Discovery Aldol condensation Iso-cladospolide B Biochemistry Stereocenter
Zdroj:	Tetrahedron Letters. 47:6537-6540
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2006.07.044
Popis:	The syntheses of iso-cladospolide-B, cladospolide-B and cladospolide-C are reported with 4S,5S,11S-configuration. Of the three stereogenic centres, the C-4/C-5 vic-diol was created by Evans aldol condensation, while the C-11 stereocentre was created by Jacobsen’s method. The synthesis of cladospolides 1–3 defined the absolute stereochemistry of these natural products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d0272b63e1bc73e986a7752718677932 https://doi.org/10.1016/j.tetlet.2006.07.044 Zobrazit plný text záznamu Full Text from ScienceDirect