A transient increase in histone H2A ubiquitination is coincident with the onset of erythroleukemic cell differentiation

Autor:	David E. Housman, Paul S. Swerdlow, Jack O. Hensold
Rok vydání:	1988
Předmět:	biology Cellular differentiation Immunology Cell Biology Hematology Biochemistry Molecular biology Chromatin Histone Ubiquitin Histone H2A ubiquitination Histone H2A biology.protein Inducer sense organs Nuclear protein
Zdroj:	Blood. 71:1153-1156
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v71.4.1153.1153
Popis:	Murine erythroleukemia cells are useful for studying the regulation of erythroid differentiation since these malignant pronormoblasts differentiate to orthochromatic normoblasts when treated with a variety of inducing agents. Changes in chromatin proteins have been described following inducer exposure. The significance of these changes, which are greatest in terminally differentiated cells remains unknown. Ubiquitin is a highly conserved 8.5 kilodalton peptide that is covalently linked to up to 10% of histone H2A. We demonstrate that following exposure of MEL cells to inducers of differentiation, a transient increase in ubiquitination of H2A occurs. This change is coincident with the onset of differentiation. This result suggests that ubiquitination of H2A may have a role in the nuclear changes necessary for erythroleukemic cell differentiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d023ca4ff00c010a1679b252ff305e6d https://doi.org/10.1182/blood.v71.4.1153.1153 Zobrazit plný text záznamu