Contribution of serotonergic and nitrergic pathways, as well as monoamine oxidase-a and Na+, K+-ATPase enzymes in antidepressant-like action of ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide (BMMS)
| Autor: | Cristiane Luchese, Marina Laura C.P. Torres, Renata L. de Oliveira, Marina C. Dilelio, Jaini J. Paltian, Mikaela P. Pinz, Michele P Moreira, Guilherme T. Voss, Claudio C. Silveira, Ethel A. Wilhelm |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Ketanserin Monoamine oxidase Chemistry medicine.drug_class Pharmacology Receptor antagonist Serotonergic Biochemistry Tail suspension test 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine medicine NMDA receptor Neurology (clinical) Serotonin Na+/K+-ATPase 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Metabolic Brain Disease. 34:1313-1324 |
| ISSN: | 1573-7365 0885-7490 |
| DOI: | 10.1007/s11011-019-00436-x |
| Popis: | The present study investigated a possible antidepressant-like effect of ((4-tert-butylcyclohexylidene)methyl) (4-methoxystyryl) sulfide (BMMS) by using the forced swimming test (FST) and the tail suspension test (TST) in Swiss mice. The contribution of serotoninergic, glutamatergic and nitrergic systems in the antidepressant-like activity of BMMS was evaluated. We also examined the involvement of monoamine oxidase (MAO)-A, MAO-B and Na+, K+-ATPase activities in prefrontal cortex of mice. BMMS, (0.1–10 mg/kg, intragastrically (i.g.)) and fluoxetine (32 mg/kg, i.g.) decreased the immobility time in the FST and TST. The anti-immobility effect of BMMS (10 mg/kg, i.g.) in the TST was prevented by the pretreatment of mice with WAY100635 (0.1 mg/kg, subcutaneously (s.c.), a 5-HT1A receptor antagonist), ketanserin (5 mg/kg, intraperitoneal (i.p.), a 5-HT2A/2C receptor antagonist), and partially blocked by ondansetron (1 mg/kg, i.p., a 5-HT3 receptor antagonist). The anti-immobility effect of BMMS (10 mg / kg, i.g.) was not avoided by pretreatment with MK-801 (0.01 mg/kg, s.c. a non-competitive N-methyl D-Aspartate (NMDA) receptor) in the TST. Pretreatment with L-arginine (500 mg/kg, i.p., a nitric oxide precursor) reversed partially the reduction in the immobility time elicited by BMMS (10 mg/kg, i.g.) in TST. BMMS altered Na+,K+-ATPase and MAO-A activities in prefrontal cortex of mice, but was not able to change the MAO-B activity. In conclusion, BMMS exerted an antidepressant-like effect in mice and serotonergic and nitrergic systems are involved in the antidepressant-like action of compound. BMMS modulated MAO-A and Na+, K+- ATPase activities in prefrontal cortex of mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink