Chapter 20. Cyclic Nucleotides as Mediators of Drug Action
| Autor: | Amer Ms, Mckinney Gr |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Vascular smooth muscle business.industry Stimulation Drug action Pharmacology Apomorphine Adenylyl cyclase chemistry.chemical_compound Endocrinology Mechanism of action chemistry Internal medicine medicine Catecholamine Cyclic adenosine monophosphate medicine.symptom business medicine.drug |
| DOI: | 10.1016/s0065-7743(08)61008-8 |
| Popis: | Publisher Summary This chapter discusses the mediator role of cyclic nucleotides in the mechanism of action of drugs according to the organ system on which the drugs exert their actions such as drugs acting on the nervous system, drugs acting on the cardiovascular system, drugs affecting the gastrointestinal tract, and drugs that affect the immune response. Drugs acting on the nervous system include morphin, apomorphine, ethanol, and local anesthetics. That the analgesic activity of morphine or similarly acting drugs may be mediated via the elevation of intracellular cyclic adenosine monophosphate (AMP) levels in the midbrain-thalamus has been demonstrated. There is also a suggestion that local anesthetics may act via increasing the intracellular concentrations of cyclic AMP. A large effort has been devoted to understanding the role that cyclic nucleotides play in cardiac function. As far as drugs are concerned, those catecholamine derivatives that stimulate the 0-adrenergic receptors,example isoproterenol, appear to act via adenylyl cyclase stimulation and the consequent accumulation of cyclic AMP. The cyclic nucleotides also appear to mediate the antihypertensive activity of many drugs at the level of the vascular smooth muscle irrespective of their mechanism of action. The drugs that lower intraocular pressure the possible mediator role of cyclic AMP in the action of drugs used to lower the elevated intraocular pressure in glaucoma is currently being examined. It appears that lowering intraoclar pressure is accompanied by a rise in the cyclic AMP content of the aqueous humor although the site of cyclic AMP production is not clearly defined. |
| Databáze: | OpenAIRE |
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