Increase of elastic fibers in lichen sclerosus et atrophicus

Autor:	Norihiro Fujimoto, Koji Ono, Yohei Shiba, Minoru Akiyama, Shingo Tajima
Rok vydání:	2014
Předmět:	Pathology medicine.medical_specialty Histology biology Chemistry Dermatology Anatomy Lichen sclerosus medicine.disease Pathology and Forensic Medicine medicine.anatomical_structure Dermis biology.protein medicine Van Gieson's stain In patient Elastin Elastic fiber Hyaline
Zdroj:	Journal of Cutaneous Pathology. 41:646-649
ISSN:	0303-6987
DOI:	10.1111/cup.12342
Popis:	Background Lichen sclerosus et atrophicus (LSA) is histopathologically characterized by upper dermal hyalinization with vacuolar alteration, whereas no particular microscopic change in the mid to lower dermis has been described. The purpose of this study was to investigate any histopathologic changes involving elastic fibers in the mid to lower dermis in patients with LSA. Methods We surveyed 22 paraffin-embedded specimens of vulval (18 cases) and extragenital (4 cases) LSA. The sliced skin sections were stained with elastic van Gieson (EVG), and then the degree of elastic fiber change was determined. Results We found an increase in elastic fibers in the mid to lower dermis in contrast to a decrease or disappearance of elastic fibers in the superficial hyalinized dermis. The level of increase of elastic fibers varies from normal (8/22 cases) to moderate (7/22 cases) to advanced (7/22 cases) levels. Conclusions An increase in elastic fibers in the mid to lower dermis may reflect a repairing process in response to the degraded upper dermal elastic fibers, which could be related to the pathogenesis of LSA.
Databáze:	OpenAIRE
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