The effect of mutations of the kynurenine pathway of tryptophan metabolism on locomotor behavior and gene expression in glutamatergic and cholinergic systems of D. melanogaster
| Autor: | Aleksandr V. Zhuravlev, N. G. Kamyshov, Tatyana L Payalina, E. V. Savvateeva-Popova, G. A. Zakharov |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Kynurenine pathway fungi 3-Hydroxykynurenine Biology chemistry.chemical_compound Glutamatergic Kynurenic acid Endocrinology chemistry Internal medicine Genetics medicine Cholinergic Animal Science and Zoology Indoleamine 2 3-dioxygenase Agronomy and Crop Science Kynurenine Ionotropic effect |
| Zdroj: | Russian Journal of Genetics: Applied Research. 2:197-204 |
| ISSN: | 2079-0600 2079-0597 |
| DOI: | 10.1134/s2079059712020141 |
| Popis: | Kynurenine disbalance induced by mutations of the kynurenine path of tryptophan metabolism in drosophilae has an effect on the locomotor behavior of larvae. Excessive concentrations of kynurenic acid in the cinnabar mutant caused a dramatic decline in the activity. The effects of mutations apparently depend on the modulatory effect of kynurenines on the signal pathways regulated by ionotropic glutamatergic and cholinergic receptors. The age dynamics of their genes’ expression is evidence for progressive development of disorders induced by kynurenine disbalance. |
| Databáze: | OpenAIRE |
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