Abstract P106: Elevated Fasting Glucose and Proteinuria in Offspring Born to Gestational Hypertensive African Green Monkeys
| Autor: | Chelsea C Weaver, Jeffrey L. Osborn, Jessica C Taylor |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Gestational hypertension
Pregnancy Fetus Proteinuria Offspring business.industry Renal function Physiology 030204 cardiovascular system & hematology medicine.disease Preeclampsia 03 medical and health sciences 0302 clinical medicine Internal Medicine medicine Gestation 030212 general & internal medicine medicine.symptom business |
| Zdroj: | Hypertension. 74 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Preeclampsia (PreE), or gestational hypertension (GH) concurrent with proteinuria, is a leading cause of maternal and fetal mortality worldwide. PreE often leads to fetal growth restriction resulting in low birth weight offspring. Low birth weight infants are at higher risk of developing cardiovascular disease later in life. The African Green Monkey (AGM; Chlorocebus aethiops sabaeus ) develops spontaneous GH with proteinuria and fetal growth restriction. We hypothesize that GH will developmentally program offspring to reduced kidney function and metabolic disease. Maternal systolic arterial pressure (SAP) was measured via forearm plethysmography prior to pregnancy and during the 3 rd trimester of pregnancy. At 1-3 years of age, offspring were single-housed for water intake and urine flow rate collections followed by blood pressure measurement and venous blood sampling. Animals were grouped by pregnancy phenotype. SAP for normotensive (NT, n=23) mothers did not change in pregnancy, but increased during third trimester for GH (Δ=35 ± 7 mmHg, n=34). NT pregnancies resulted in a 4% stillbirth rate (1/23) compared with 29% in GH (10/34). Surviving GH offspring had reduced birth weight (NT 336 ± 11g vs. GH 295 ± 8g, pin utero programming of the pathogenesis of cardiovascular and metabolic disease. |
| Databáze: | OpenAIRE |
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