Limonoids from Cipadessa baccifera
| Autor: | Jian-Min Yue, Flavia M. Zimbres, Bin Zhou, Maria B. Cassera, Qun-Fang Liu, Jin-Hai Yu, Seema Dalal, Hua Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Residue (complex analysis) 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Pharmaceutical Science Nuclear magnetic resonance spectroscopy 01 natural sciences Nmr data Quantum chemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Cipadessa baccifera Complementary and alternative medicine Drug Discovery X-ray crystallography Ic50 values Molecular Medicine Molecule |
| Zdroj: | Journal of Natural Products. 83:1751-1765 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.9b00666 |
| Popis: | Eighteen new limonoids, including eight methyl angolensates (1-8) and 10 cipadesins (9-18), were isolated from the leaves of Cipadessa baccifera. Their structures were characterized by means of spectroscopic data analyses, single-crystal X-ray diffraction, and quantum chemistry computational methods. The C-6 configurations in those compounds possessing a C-6 hydroxy group were all assigned as S regardless of the magnitude of J5,6, and the C-2' configuration in those bearing a 2-methylbutyryl residue was defined by single-crystal X-ray diffraction and NMR data. Compounds 1, 5, 6, 7, 11, and 12 showed moderate antimalarial activities with IC50 values ranging from 12 to 28 μM. |
| Databáze: | OpenAIRE |
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